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Molecular Structures of Quiescently Grown and Brain-Derived Polymorphic Fibrils of the Alzheimer Amyloid Aβ(9-40) Peptide: A Comparison to Agitated Fibrils

The presence of amyloid deposits consisting primarily of Amyloid-β (Aβ) fibril in the brain is a hallmark of Alzheimer's disease (AD). The morphologies of these fibrils are exquisitely sensitive to environmental conditions. Using molecular dynamics simulations combined with data from previously...

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Detalles Bibliográficos
Autores principales: Wu, Chun, Bowers, Michael T., Shea, Joan-Emma
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832665/
https://www.ncbi.nlm.nih.gov/pubmed/20221247
http://dx.doi.org/10.1371/journal.pcbi.1000693