Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

BACKGROUND: Mutations in LRRK2, the gene that encodes leucine-rich repeat kinase 2, are a cause of Parkinson's disease (PD). The International LRRK2 Consortium was established to answer three key clinical questions: can LRRK2-associated PD be distinguished from idiopathic PD; which mutations in...

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Detalles Bibliográficos
Autores principales: Healy, Daniel G, Falchi, Mario, O'Sullivan, Sean S, Bonifati, Vincenzo, Durr, Alexandra, Bressman, Susan, Brice, Alexis, Aasly, Jan, Zabetian, Cyrus P, Goldwurm, Stefano, Ferreira, Joaquim J, Tolosa, Eduardo, Kay, Denise M, Klein, Christine, Williams, David R, Marras, Connie, Lang, Anthony E, Wszolek, Zbigniew K, Berciano, Jose, Schapira, Anthony HV, Lynch, Timothy, Bhatia, Kailash P, Gasser, Thomas, Lees, Andrew J, Wood, Nicholas W
Formato: Texto
Lenguaje:English
Publicado: Lancet Pub. Group 2008
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832754/
https://www.ncbi.nlm.nih.gov/pubmed/18539534
http://dx.doi.org/10.1016/S1474-4422(08)70117-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832754/
https://www.ncbi.nlm.nih.gov/pubmed/18539534
http://dx.doi.org/10.1016/S1474-4422(08)70117-0

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