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Roles of B cells in rheumatoid arthritis
B lymphocytes play several critical roles in the pathogenesis of rheumatoid arthritis. They are the source of the rheumatoid factors and anticitrullinated protein antibodies, which contribute to immune complex formation and complement activation in the joints. B cells are also very efficient antigen...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2003
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2833442/ https://www.ncbi.nlm.nih.gov/pubmed/15180890 http://dx.doi.org/10.1186/ar1010 |
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author | Silverman, Gregg J Carson, Dennis A |
author_facet | Silverman, Gregg J Carson, Dennis A |
author_sort | Silverman, Gregg J |
collection | PubMed |
description | B lymphocytes play several critical roles in the pathogenesis of rheumatoid arthritis. They are the source of the rheumatoid factors and anticitrullinated protein antibodies, which contribute to immune complex formation and complement activation in the joints. B cells are also very efficient antigen-presenting cells, and can contribute to T cell activation through expression of costimulatory molecules. B cells both respond to and produce the chemokines and cytokines that promote leukocyte infiltration into the joints, formation of ectopic lymphoid structures, angiogenesis, and synovial hyperplasia. The success of B cell depletion therapy in rheumatoid arthritis may depend on disruption of all these diverse functions. |
format | Text |
id | pubmed-2833442 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2003 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-28334422010-03-08 Roles of B cells in rheumatoid arthritis Silverman, Gregg J Carson, Dennis A Arthritis Res Ther Review B lymphocytes play several critical roles in the pathogenesis of rheumatoid arthritis. They are the source of the rheumatoid factors and anticitrullinated protein antibodies, which contribute to immune complex formation and complement activation in the joints. B cells are also very efficient antigen-presenting cells, and can contribute to T cell activation through expression of costimulatory molecules. B cells both respond to and produce the chemokines and cytokines that promote leukocyte infiltration into the joints, formation of ectopic lymphoid structures, angiogenesis, and synovial hyperplasia. The success of B cell depletion therapy in rheumatoid arthritis may depend on disruption of all these diverse functions. BioMed Central 2003 2003-12-02 /pmc/articles/PMC2833442/ /pubmed/15180890 http://dx.doi.org/10.1186/ar1010 Text en Copyright ©2003 BioMed Central Ltd |
spellingShingle | Review Silverman, Gregg J Carson, Dennis A Roles of B cells in rheumatoid arthritis |
title | Roles of B cells in rheumatoid arthritis |
title_full | Roles of B cells in rheumatoid arthritis |
title_fullStr | Roles of B cells in rheumatoid arthritis |
title_full_unstemmed | Roles of B cells in rheumatoid arthritis |
title_short | Roles of B cells in rheumatoid arthritis |
title_sort | roles of b cells in rheumatoid arthritis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2833442/ https://www.ncbi.nlm.nih.gov/pubmed/15180890 http://dx.doi.org/10.1186/ar1010 |
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