Oncolytic and immunostimulatory efficacy of a targeted oncolytic poxvirus expressing human GM-CSF following intravenous administration in a rabbit tumor model

Targeted oncolytic poxviruses hold promise for the treatment of cancer. Arming these agents with immunostimulatory cytokines (for example, granulocyte-monocyte colony-stimulating factor; GM-CSF) can potentially increase their efficacy and/or alter their safety. However, due to species-specific diffe...

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Detalles Bibliográficos
Autores principales: Lee, J-H, Roh, M-S, Lee, Y-K, Kim, M-K, Han, J-Y, Park, B-H, Trown, P, Kirn, D H, Hwang, T-H
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834359/
https://www.ncbi.nlm.nih.gov/pubmed/19629143
http://dx.doi.org/10.1038/cgt.2009.50

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834359/
https://www.ncbi.nlm.nih.gov/pubmed/19629143
http://dx.doi.org/10.1038/cgt.2009.50

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