Fumarase: A Mitochondrial Metabolic Enzyme and a Cytosolic/Nuclear Component of the DNA Damage Response

In eukaryotes, fumarase (FH in human) is a well-known tricarboxylic-acid-cycle enzyme in the mitochondrial matrix. However, conserved from yeast to humans is a cytosolic isoenzyme of fumarase whose function in this compartment remains obscure. A few years ago, FH was surprisingly shown to underlie a...

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Detalles Bibliográficos
Autores principales: Yogev, Ohad, Yogev, Orli, Singer, Esti, Shaulian, Eitan, Goldberg, Michal, Fox, Thomas D., Pines, Ophry
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834712/
https://www.ncbi.nlm.nih.gov/pubmed/20231875
http://dx.doi.org/10.1371/journal.pbio.1000328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834712/
https://www.ncbi.nlm.nih.gov/pubmed/20231875
http://dx.doi.org/10.1371/journal.pbio.1000328

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