Regulation of UGT1A1 and HNF1 transcription factor gene expression by DNA methylation in colon cancer cells

BACKGROUND: UDP-glucuronosyltransferase 1A1 (UGT1A1) is a pivotal enzyme involved in metabolism of SN-38, the active metabolite of irinotecan commonly used to treat metastatic colorectal cancer. We previously demonstrated aberrant methylation of specific CpG dinucleotides in UGT1A1-negative cells, a...

Descripción completa

Detalles Bibliográficos
Autores principales: Bélanger, Anne-Sophie, Tojcic, Jelena, Harvey, Mario, Guillemette, Chantal
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835698/
https://www.ncbi.nlm.nih.gov/pubmed/20096102
http://dx.doi.org/10.1186/1471-2199-11-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835698/
https://www.ncbi.nlm.nih.gov/pubmed/20096102
http://dx.doi.org/10.1186/1471-2199-11-9

Ejemplares similares