Cargando…

Regulation of UGT1A1 and HNF1 transcription factor gene expression by DNA methylation in colon cancer cells

BACKGROUND: UDP-glucuronosyltransferase 1A1 (UGT1A1) is a pivotal enzyme involved in metabolism of SN-38, the active metabolite of irinotecan commonly used to treat metastatic colorectal cancer. We previously demonstrated aberrant methylation of specific CpG dinucleotides in UGT1A1-negative cells, a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bélanger, Anne-Sophie, Tojcic, Jelena, Harvey, Mario, Guillemette, Chantal
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835698/ https://www.ncbi.nlm.nih.gov/pubmed/20096102 http://dx.doi.org/10.1186/1471-2199-11-9

Ejemplares similares

Differential regulation of serum microRNA expression by HNF1β and HNF1α transcription factors
por: Fendler, Wojciech, et al.
Publicado: (2016)

Differences in UGT1A1, UGT1A7, and UGT1A9 Polymorphisms between Uzbek and Japanese Populations
por: Maeda, Hiromichi, et al.
Publicado: (2014)

Profiling of UGT1A1(*)6, UGT1A1(*)60, UGT1A1(*)93, and UGT1A1(*)28 Polymorphisms in Indonesian Neonates With Hyperbilirubinemia Using Multiplex PCR Sequencing
por: Amandito, Radhian, et al.
Publicado: (2019)

Epistasis of Transcriptomes Reveals Synergism between Transcriptional Activators Hnf1α and Hnf4α
por: Boj, Sylvia F., et al.
Publicado: (2010)

Reply to Comment on “UGT2B17 modifies drug response in chronic lymphocytic leukaemia”
por: Guillemette, Chantal, et al.
Publicado: (2020)

Species-Specific Differences in the Expression of the HNF1A, HNF1B and HNF4A Genes
por: Harries, Lorna W., et al.
Publicado: (2009)

Commentary: Profiling of UGT1A1(*)6, UGT1A1(*)60, UGT1A1(*)93, and UGT1A1(*)28 Polymorphisms in Indonesian Neonates With Hyperbilirubinemia Using Multiplex PCR Sequencing
por: Heydari, Mohammad Reza, et al.
Publicado: (2020)

Polymorphisms of UGT1A1(*)6, UGT1A1(*)27 & UGT1A1(*)28 in three major ethnic groups from Malaysia
por: Teh, L. K., et al.
Publicado: (2012)

Genotyping of UGT1A1*80 as an Alternative to UGT1A1*28 Genotyping in Spain
por: Bravo-Gómez, Adrián, et al.
Publicado: (2022)

Berry Phenolic Compounds Increase Expression of Hepatocyte Nuclear Factor-1α (HNF-1α) in Caco-2 and Normal Colon Cells Due to High Affinities with Transcription and Dimerization Domains of HNF-1α
por: Real Hernandez, Luis M., et al.
Publicado: (2015)

UGT1A1 and UGT1A9 Are Responsible for Phase II Metabolism of Tectorigenin and Irigenin In Vitro
por: Li, Ji, et al.
Publicado: (2022)

Regulation of High-Altitude Hypoxia on the Transcription of CYP450 and UGT1A1 Mediated by PXR and CAR
por: Duan, Ya-bin, et al.
Publicado: (2020)

Epigenetics and microRNAs in UGT1As
por: Meng, Cui-Lan, et al.
Publicado: (2021)

Improved Progression-Free Survival in Irinotecan-Treated Metastatic Colorectal Cancer Patients Carrying the HNF1A Coding Variant p.I27L
por: Labriet, Adrien, et al.
Publicado: (2017)

The HNF1α-regulated lncRNA HNF1A-AS1 reverses the malignancy of hepatocellular carcinoma by enhancing the phosphatase activity of SHP-1
por: Ding, Chen-Hong, et al.
Publicado: (2018)

Effects of ABCB1, UGT1A1, and UGT1A9 Genetic Polymorphisms on the Pharmacokinetics of Sitafloxacin Granules in Healthy Subjects
por: Sun, Lu‐Ning, et al.
Publicado: (2020)

Functional Targets of the Monogenic Diabetes Transcription Factors HNF-1α and HNF-4α Are Highly Conserved Between Mice and Humans
por: Boj, Sylvia F., et al.
Publicado: (2009)

HNF4G accelerates glioma progression by facilitating NRP1 transcription
por: Che, Hongmin, et al.
Publicado: (2023)

Combined effect of regulatory polymorphisms on transcription of UGT1A1 as a cause of Gilbert syndrome
por: Matsui, Katsuyuki, et al.
Publicado: (2010)

Assessment of the HNF1B Score as a Tool to Select Patients for HNF1B Genetic Testing
por: Clissold, Rhian, et al.
Publicado: (2015)

USF1 Transcriptionally Regulates UGT1A3 and Promotes Lung Adenocarcinoma Progression by Regulating Neurotrophin Signaling Pathway
por: Wang, Yu, et al.
Publicado: (2022)

The Roles of Long Noncoding RNAs HNF1α-AS1 and HNF4α-AS1 in Drug Metabolism and Human Diseases
por: Chen, Liming, et al.
Publicado: (2020)

Mechanisms of ion transport regulation by HNF1β in the kidney: beyond transcriptional regulation of channels and transporters
por: Tholen, Lotte E., et al.
Publicado: (2022)

Relationship between UGT1A1*27 and UGT1A1*7 polymorphisms and irinotecan‐related toxicities in patients with lung cancer
por: Fukuda, Minoru, et al.
Publicado: (2017)

An HNF1α truncation associated with maturity-onset diabetes of the young impairs pancreatic progenitor differentiation by antagonizing HNF1β function
por: Cujba, Ana-Maria, et al.
Publicado: (2022)

HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer
por: Ross-Adams, Helen, et al.
Publicado: (2016)

Association of gallstone and polymorphisms of UGT1A1*27 and UGT1A1*28 in patients with hepatitis B virus-related liver failure
por: Zhuo, Haiyan, et al.
Publicado: (2022)

Establishment of UGT1A1-knockout human iPS-derived hepatic organoids for UGT1A1-specific kinetics and toxicity evaluation
por: Shintani, Tomohiro, et al.
Publicado: (2023)

Impacts of the Glucuronidase Genotypes UGT1A4, UGT2B7, UGT2B15 and UGT2B17 on Tamoxifen Metabolism in Breast Cancer Patients
por: Romero-Lorca, Alicia, et al.
Publicado: (2015)

Disruption of Tumor Suppressors HNF4α/HNF1α Causes Tumorigenesis in Liver
por: Teeli, Aamir Salam, et al.
Publicado: (2021)

Reduction of p53 by Knockdown of the UGT1 Locus in Colon Epithelial Cells Causes an Increase in Tumorigenesis
por: Liu, Miao, et al.
Publicado: (2015)

Isothiocyanates induce UGT1A1 in humanized UGT1 mice in a CAR dependent fashion that is highly dependent upon oxidative stress
por: Yoda, Emiko, et al.
Publicado: (2017)

Correction to: Mechanisms of ion transport regulation by HNF1β in the kidney: beyond transcriptional regulation of channels and transporters
por: Tholen, Lotte E., et al.
Publicado: (2022)

Correction: Impacts of the Glucuronidase Genotypes UGT1A4, UGT2B7, UGT2B15 and UGT2B17 on Tamoxifen Metabolism in Breast Cancer Patients
Publicado: (2015)

Hnf-1β Transcription Factor Is an Early Hif-1α-Independent Marker of Epithelial Hypoxia and Controls Renal Repair
por: Faguer, Stanislas, et al.
Publicado: (2013)

Quantitative Systems Pharmacology Model of hUGT1A1‐modRNA Encoding for the UGT1A1 Enzyme to Treat Crigler‐Najjar Syndrome Type 1
por: Apgar, Joshua F., et al.
Publicado: (2018)

Complete Reaction Phenotyping of Propranolol and 4-Hydroxypropranolol with the 19 Enzymes of the Human UGT1 and UGT2 Families
por: Yang, Fan, et al.
Publicado: (2022)

UGT1A1 polymorphisms in cancer: impact on irinotecan treatment
por: Takano, Masashi, et al.
Publicado: (2017)

UGT1A1-related Bilirubin Encephalopathy/Kernicterus in Adults
por: Bai, Jie, et al.
Publicado: (2021)

Identification of Novel UGT1A1 Variants Including UGT1A1 454C>A through the Genotyping of Healthy Participants of the HPTN 077 Study
por: Seneviratne, Herana Kamal, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_0njdbgldcvpjm66e2j4jh99893