Pathogenic Polyglutamine Tracts Are Potent Inducers of Spontaneous Sup35 and Rnq1 Amyloidogenesis

The glutamine/asparagine (Q/N)-rich yeast prion protein Sup35 has a low intrinsic propensity to spontaneously self-assemble into ordered, β-sheet-rich amyloid fibrils. In yeast cells, de novo formation of Sup35 aggregates is greatly facilitated by high protein concentrations and the presence of pref...

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Detalles Bibliográficos
Autores principales: Goehler, Heike, Dröge, Anja, Lurz, Rudi, Schnoegl, Sigrid, Chernoff, Yury O., Wanker, Erich E.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835767/
https://www.ncbi.nlm.nih.gov/pubmed/20224794
http://dx.doi.org/10.1371/journal.pone.0009642

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835767/
https://www.ncbi.nlm.nih.gov/pubmed/20224794
http://dx.doi.org/10.1371/journal.pone.0009642

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