Mitotic chromosomes are constrained by topoisomerase II–sensitive DNA entanglements

We have analyzed the topological organization of chromatin inside mitotic chromosomes. We show that mitotic chromatin is heavily self-entangled through experiments in which topoisomerase (topo) II is observed to reduce mitotic chromosome elastic stiffness. Single chromosomes were relaxed by 35% by e...

Descripción completa

Detalles Bibliográficos
Autores principales: Kawamura, Ryo, Pope, Lisa H., Christensen, Morten O., Sun, Mingxuan, Terekhova, Ksenia, Boege, Fritz, Mielke, Christian, Andersen, Anni H., Marko, John F.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835934/
https://www.ncbi.nlm.nih.gov/pubmed/20194637
http://dx.doi.org/10.1083/jcb.200910085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835934/
https://www.ncbi.nlm.nih.gov/pubmed/20194637
http://dx.doi.org/10.1083/jcb.200910085

Ejemplares similares