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Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase
Maintenance of genome integrity is of critical importance to cells. To identify key regulators of genomic integrity, we screened a human cell line with a kinome small interfering RNA library. WEE1, a major regulator of mitotic entry, and CHK1 were among the genes identified. Both kinases are importa...
| Autores principales: | , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835936/ https://www.ncbi.nlm.nih.gov/pubmed/20194642 http://dx.doi.org/10.1083/jcb.200905059 |