Site-directed mutagenesis reveals a unique requirement for tyrosine residues in IL-7Rα and TSLPR cytoplasmic domains in TSLP-dependent cell proliferation

BACKGROUND: Thymic stromal lymphopoietin (TSLP) is an interleukin-7 (IL-7) like cytokine, which plays an important role in the regulation of immune responses to allergens. TSLP binds to a heterodimeric receptor complex composed of the IL-7 receptor α chain (IL-7Rα) and the TSLP receptor (TSLPR, also...

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Detalles Bibliográficos
Autores principales: Zhong, Jun, Pandey, Akhilesh
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836284/
https://www.ncbi.nlm.nih.gov/pubmed/20144186
http://dx.doi.org/10.1186/1471-2172-11-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836284/
https://www.ncbi.nlm.nih.gov/pubmed/20144186
http://dx.doi.org/10.1186/1471-2172-11-5

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