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A dual function TAR Decoy serves as an anti-HIV siRNA delivery vehicle
The TAR RNA of HIV was engineered as an siRNA delivery vehicle to develop a combinatorial therapeutic approach. The TAR backbone was found to be a versatile backbone for expressing siRNAs. Upon expression in human cells, pronounced and specific inhibition of reporter gene expression was observed wit...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836314/ https://www.ncbi.nlm.nih.gov/pubmed/20144240 http://dx.doi.org/10.1186/1743-422X-7-33 |