Genetic and Epigenetic Somatic Alterations in Head and Neck Squamous Cell Carcinomas Are Globally Coordinated but Not Locally Targeted

BACKGROUND: Solid tumors, including head and neck squamous cell carcinomas (HNSCC), arise as a result of genetic and epigenetic alterations in a sustained stress environment. Little work has been done that simultaneously examines the spectrum of both types of changes in human tumors on a genome-wide...

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Detalles Bibliográficos
Autores principales: Poage, Graham M., Christensen, Brock C., Houseman, E. Andres, McClean, Michael D., Wiencke, John K., Posner, Marshall R., Clark, John R., Nelson, Heather H., Marsit, Carmen J., Kelsey, Karl T.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836370/
https://www.ncbi.nlm.nih.gov/pubmed/20300172
http://dx.doi.org/10.1371/journal.pone.0009651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836370/
https://www.ncbi.nlm.nih.gov/pubmed/20300172
http://dx.doi.org/10.1371/journal.pone.0009651

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