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Genetic and Epigenetic Somatic Alterations in Head and Neck Squamous Cell Carcinomas Are Globally Coordinated but Not Locally Targeted

BACKGROUND: Solid tumors, including head and neck squamous cell carcinomas (HNSCC), arise as a result of genetic and epigenetic alterations in a sustained stress environment. Little work has been done that simultaneously examines the spectrum of both types of changes in human tumors on a genome-wide...

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Detalles Bibliográficos
Autores principales:	Poage, Graham M., Christensen, Brock C., Houseman, E. Andres, McClean, Michael D., Wiencke, John K., Posner, Marshall R., Clark, John R., Nelson, Heather H., Marsit, Carmen J., Kelsey, Karl T.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836370/ https://www.ncbi.nlm.nih.gov/pubmed/20300172 http://dx.doi.org/10.1371/journal.pone.0009651

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