Reduced nuclear export of HuR mRNA by HuR is linked to the loss of HuR in replicative senescence

The RNA-binding protein, HuR, associates with the HuR mRNA, but the consequences of this interaction are unknown. Here, we use human diploid fibroblasts (HDFs) and cervical carcinoma cells to study this regulatory paradigm. Ectopic overexpression of HuR potently enhanced the translation and cytoplas...

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Detalles Bibliográficos
Autores principales: Yi, Jie, Chang, Na, Liu, Xinwen, Guo, Gaier, Xue, Lixiang, Tong, Tanjun, Gorospe, Myriam, Wang, Wengong
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836555/
https://www.ncbi.nlm.nih.gov/pubmed/20007147
http://dx.doi.org/10.1093/nar/gkp1114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836555/
https://www.ncbi.nlm.nih.gov/pubmed/20007147
http://dx.doi.org/10.1093/nar/gkp1114

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