Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria

The Cfr methyltransferase confers combined resistance to five classes of antibiotics that bind to the peptidyl tranferase center of bacterial ribosomes by catalyzing methylation of the C-8 position of 23S rRNA nucleotide A2503. The same nucleotide is targeted by the housekeeping methyltransferase Rl...

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Detalles Bibliográficos
Autores principales: Kaminska, Katarzyna H., Purta, Elzbieta, Hansen, Lykke H., Bujnicki, Janusz M., Vester, Birte, Long, Katherine S.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836569/
https://www.ncbi.nlm.nih.gov/pubmed/20007606
http://dx.doi.org/10.1093/nar/gkp1142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836569/
https://www.ncbi.nlm.nih.gov/pubmed/20007606
http://dx.doi.org/10.1093/nar/gkp1142

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