Gene silencing by cell-penetrating, sequence-selective and nucleic-acid hydrolyzing antibodies

Targeting particular mRNAs for degradation is a fascinating approach to achieve gene silencing. Here we describe a new gene silencing tool exploiting a cell-penetrating, nucleic-acid hydrolyzing, single-domain antibody of the light-chain variable domain, 3D8 VL. We generated a synthetic library of 3...

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Detalles Bibliográficos
Autores principales: Lee, Woo-Ram, Jang, Ji-Young, Kim, Jeong-Sun, Kwon, Myung-Hee, Kim, Yong-Sung
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836572/
https://www.ncbi.nlm.nih.gov/pubmed/20007602
http://dx.doi.org/10.1093/nar/gkp1145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836572/
https://www.ncbi.nlm.nih.gov/pubmed/20007602
http://dx.doi.org/10.1093/nar/gkp1145

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