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Gene silencing by cell-penetrating, sequence-selective and nucleic-acid hydrolyzing antibodies

Targeting particular mRNAs for degradation is a fascinating approach to achieve gene silencing. Here we describe a new gene silencing tool exploiting a cell-penetrating, nucleic-acid hydrolyzing, single-domain antibody of the light-chain variable domain, 3D8 VL. We generated a synthetic library of 3...

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Detalles Bibliográficos
Autores principales:	Lee, Woo-Ram, Jang, Ji-Young, Kim, Jeong-Sun, Kwon, Myung-Hee, Kim, Yong-Sung
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2010
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836572/ https://www.ncbi.nlm.nih.gov/pubmed/20007602 http://dx.doi.org/10.1093/nar/gkp1145

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