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The N-terminus of Prp1 (Prp6/U5-102 K) is essential for spliceosome activation in vivo
The spliceosomal protein Prp1 (Prp6/U5-102 K) is necessary for the integrity of pre-catalytic spliceosomal complexes. We have identified a novel regulatory function for Prp1. Expression of mutations in the N-terminus of Prp1 leads to the accumulation of pre-catalytic spliceosomal complexes containin...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836577/ https://www.ncbi.nlm.nih.gov/pubmed/20007600 http://dx.doi.org/10.1093/nar/gkp1155 |