Biological and Structural Basis for Aha1 Regulation of Hsp90 ATPase Activity in Maintaining Proteostasis in the Human Disease Cystic Fibrosis

The activator of Hsp90 ATPase 1, Aha1, has been shown to participate in the Hsp90 chaperone cycle by stimulating the low intrinsic ATPase activity of Hsp90. To elucidate the structural basis for ATPase stimulation of human Hsp90 by human Aha1, we have developed novel mass spectrometry approaches tha...

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Detalles Bibliográficos
Autores principales: Koulov, Atanas V., LaPointe, Paul, Lu, Bingwen, Razvi, Abbas, Coppinger, Judith, Dong, Meng-Qiu, Matteson, Jeanne, Laister, Rob, Arrowsmith, Cheryl, Yates, John R., Balch, William E.
Formato: Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2010
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836968/
https://www.ncbi.nlm.nih.gov/pubmed/20089831
http://dx.doi.org/10.1091/mbc.E09-12-1017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836968/
https://www.ncbi.nlm.nih.gov/pubmed/20089831
http://dx.doi.org/10.1091/mbc.E09-12-1017

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