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Mitochondrial Dysfunction Confers Resistance to Multiple Drugs in Caenorhabditis elegans

In a previous genetic screen for Caenorhabditis elegans mutants that survive in the presence of an antimitotic drug, hemiasterlin, we identified eight strong mutants. Two of these were found to be resistant to multiple toxins, and in one of these we identified a missense mutation in phb-2, which enc...

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Detalles Bibliográficos
Autores principales: Zubovych, Iryna O., Straud, Sarah, Roth, Michael G.
Formato: Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836976/
https://www.ncbi.nlm.nih.gov/pubmed/20089839
http://dx.doi.org/10.1091/mbc.E09-08-0673