The mitochondria-independent cytotoxic effect of nelfinavir on leukemia cells can be enhanced by sorafenib-mediated mcl-1 downregulation and mitochondrial membrane destabilization

BACKGROUND: Nelfinavir is an HIV protease inhibitor that has been used for a long period of time to treat HIV-infected individuals. It has recently emerged that nelfinavir could represent a prospective new anti-cancer drug, prompting us to test the effect of nelfinavir on leukemia cells. METHODS: By...

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Detalles Bibliográficos
Autores principales: Brüning, Ansgar, Rahmeh, Martina, Gingelmaier, Andrea, Friese, Klaus
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836985/
https://www.ncbi.nlm.nih.gov/pubmed/20105315
http://dx.doi.org/10.1186/1476-4598-9-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836985/
https://www.ncbi.nlm.nih.gov/pubmed/20105315
http://dx.doi.org/10.1186/1476-4598-9-19

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