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The mitochondria-independent cytotoxic effect of nelfinavir on leukemia cells can be enhanced by sorafenib-mediated mcl-1 downregulation and mitochondrial membrane destabilization

BACKGROUND: Nelfinavir is an HIV protease inhibitor that has been used for a long period of time to treat HIV-infected individuals. It has recently emerged that nelfinavir could represent a prospective new anti-cancer drug, prompting us to test the effect of nelfinavir on leukemia cells. METHODS: By...

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Detalles Bibliográficos
Autores principales:	Brüning, Ansgar, Rahmeh, Martina, Gingelmaier, Andrea, Friese, Klaus
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836985/ https://www.ncbi.nlm.nih.gov/pubmed/20105315 http://dx.doi.org/10.1186/1476-4598-9-19

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