Retroviral intasome assembly and inhibition of DNA strand transfer

Integrase is an essential retroviral enzyme that binds both termini of linear viral DNA and inserts them into a host cell chromosome. The structure of full-length retroviral integrase, either separately or in complex with DNA, has been lacking. Furthermore, although clinically useful inhibitors of H...

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Detalles Bibliográficos
Autores principales: Hare, Stephen, Gupta, Saumya Shree, Valkov, Eugene, Engelman, Alan, Cherepanov, Peter
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837123/
https://www.ncbi.nlm.nih.gov/pubmed/20118915
http://dx.doi.org/10.1038/nature08784

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837123/
https://www.ncbi.nlm.nih.gov/pubmed/20118915
http://dx.doi.org/10.1038/nature08784

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