Cargando…

Effects of Transcriptional Pausing on Gene Expression Dynamics

Stochasticity in gene expression affects many cellular processes and is a source of phenotypic diversity between genetically identical individuals. Events in elongation, particularly RNA polymerase pausing, are a source of this noise. Since the rate and duration of pausing are sequence-dependent, th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rajala, Tiina, Häkkinen, Antti, Healy, Shannon, Yli-Harja, Olli, Ribeiro, Andre S.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837387/ https://www.ncbi.nlm.nih.gov/pubmed/20300642 http://dx.doi.org/10.1371/journal.pcbi.1000704

Ejemplares similares

Effects of Rate-Limiting Steps in Transcription Initiation on Genetic Filter Motifs
por: Häkkinen, Antti, et al.
Publicado: (2013)

Effects of multimerization on the temporal variability of protein complex abundance
por: Häkkinen, Antti, et al.
Publicado: (2013)

In vivo kinetics of transcription initiation of the lar promoter in Escherichia coli. Evidence for a sequential mechanism with two rate-limiting steps
por: Kandhavelu, Meenakshisundaram, et al.
Publicado: (2011)

Detecting sequence dependent transcriptional pauses from RNA and protein number time series
por: Emmert-Streib, Frank, et al.
Publicado: (2012)

Inference of Kinetic Parameters of Delayed Stochastic Models of Gene Expression Using a Markov Chain Approximation
por: Mannerstrom, Henrik, et al.
Publicado: (2010)

Stochastic sequence-level model of coupled transcription and translation in prokaryotes
por: Mäkelä, Jarno, et al.
Publicado: (2011)

Cell-to-cell diversity in protein levels of a gene driven by a tetracycline inducible promoter
por: Smolander, Olli-Pekka, et al.
Publicado: (2011)

A systems biological approach to identify key transcription factors and their genomic neighborhoods in human sarcomas
por: Ylipää, Antti, et al.
Publicado: (2011)

Cancer research in the era of next-generation sequencing and big data calls for intelligent modeling
por: Yli-Hietanen, Jari, et al.
Publicado: (2015)

Dynamics of transcription driven by the tetA promoter, one event at a time, in live Escherichia coli cells
por: Muthukrishnan, Anantha-Barathi, et al.
Publicado: (2012)

Cell segmentation by multi-resolution analysis and maximum likelihood estimation (MAMLE)
por: Chowdhury, Sharif, et al.
Publicado: (2013)

Stochastic Differential Equation Model for Cerebellar Granule Cell Excitability
por: Saarinen, Antti, et al.
Publicado: (2008)

sgnesR: An R package for simulating gene expression data from an underlying real gene network structure considering delay parameters
por: Tripathi, Shailesh, et al.
Publicado: (2017)

Characterization of aberrant pathways across human cancers
por: Ylipää, Antti, et al.
Publicado: (2013)

Origins of Transcriptional Transition: Balance between Upstream and Downstream Regulatory Gene Sequences
por: Sala, Adrien, et al.
Publicado: (2015)

A protein–protein interaction guided method for competitive transcription factor binding improves target predictions
por: Laurila, Kirsti, et al.
Publicado: (2009)

Cancer systems biology: signal processing for cancer research
por: Yli-Harja, Olli, et al.
Publicado: (2011)

Robust regression for periodicity detection in non-uniformly sampled time-course gene expression data
por: Ahdesmäki, Miika, et al.
Publicado: (2007)

A joint finite mixture model for clustering genes from independent Gaussian and beta distributed data
por: Dai, Xiaofeng, et al.
Publicado: (2009)

ZebIAT, an image analysis tool for registering zebrafish embryos and quantifying cancer metastasis
por: Annila, Teppo, et al.
Publicado: (2013)

What Is a Digital Twin? Experimental Design for a Data-Centric Machine Learning Perspective in Health
por: Emmert-Streib, Frank, et al.
Publicado: (2022)

Prognostic gene expression signatures of breast cancer are lacking a sensible biological meaning
por: Manjang, Kalifa, et al.
Publicado: (2021)

Simulation of microarray data with realistic characteristics
por: Nykter, Matti, et al.
Publicado: (2006)

The elemental mechanism of transcriptional pausing
por: Saba, Jason, et al.
Publicado: (2019)

RMBNToolbox: random models for biochemical networks
por: Aho, Tommi, et al.
Publicado: (2007)

The Need for Formally Defining “Modern Medicine” by Means of Experimental Design
por: Emmert-Streib, Frank, et al.
Publicado: (2016)

Against Dataism and for Data Sharing of Big Biomedical and Clinical Data with Research Parasites
por: Emmert-Streib, Frank, et al.
Publicado: (2016)

Lessons from the Human Genome Project: Modesty, Honesty, and Realism
por: Emmert-Streib, Frank, et al.
Publicado: (2017)

Utilizing Social Media Data for Psychoanalysis to Study Human Personality
por: Emmert-Streib, Frank, et al.
Publicado: (2019)

Ensuring Quality Standards and Reproducible Research for Data Analysis Services in Oncology: A Cooperative Service Model
por: Emmert-Streib, Frank, et al.
Publicado: (2019)

Artificial Intelligence: A Clarification of Misconceptions, Myths and Desired Status
por: Emmert-Streib, Frank, et al.
Publicado: (2020)

Graph-based exploitation of gene ontology using GOxploreR for scrutinizing biological significance
por: Manjang, Kalifa, et al.
Publicado: (2020)

Information propagation within the Genetic Network of Saccharomyces cerevisiae
por: Chowdhury, Sharif, et al.
Publicado: (2010)

Visualizing translocation dynamics and nascent transcript errors in paused RNA polymerases in vivo
por: Imashimizu, Masahiko, et al.
Publicado: (2015)

Transcription Pause and Escape in Neurodevelopmental Disorders
por: Eigenhuis, Kristel N., et al.
Publicado: (2022)

Anticancer activity of THMPP: Downregulation of PI3K/ S6K1 in breast cancer cell line
por: Palanivel, Suresh, et al.
Publicado: (2020)

Data Analytics Applications for Streaming Data From Social Media: What to Predict?
por: Emmert-Streib, Frank, et al.
Publicado: (2018)

Widespread transcriptional pausing and elongation control at enhancers
por: Henriques, Telmo, et al.
Publicado: (2018)

Information Diversity in Structure and Dynamics of Simulated Neuronal Networks
por: Mäki-Marttunen, Tuomo, et al.
Publicado: (2011)

A universal transcription pause sequence is an element of initiation factor σ70-dependent pausing
por: Bird, Jeremy G., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_5hghrq1fosj0e1gedp75mcnvrs