Structural investigation of zymogenic and activated forms of human blood coagulation factor VIII: a computational molecular dynamics study

BACKGROUND: Human blood coagulation factor VIII (fVIII) is a large plasma glycoprotein with sequential domain arrangement in the order A1-a1-A2-a2-B-a3-A3-C1-C2. The A1, A2 and A3 domains are interconnected by long linker peptides (a1, a2 and a3) that possess the activation sites. Proteolysis of fVI...

Descripción completa

Detalles Bibliográficos
Autor principal: Venkateswarlu, Divi
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837666/
https://www.ncbi.nlm.nih.gov/pubmed/20184747
http://dx.doi.org/10.1186/1472-6807-10-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837666/
https://www.ncbi.nlm.nih.gov/pubmed/20184747
http://dx.doi.org/10.1186/1472-6807-10-7

Ejemplares similares