A monogenic dominant mutation in Rom1 generated by N-ethyl-N-nitrosourea mutagenesis causes retinal degeneration in mice

PURPOSE: To characterize an N-ethyl-N-nitrosourea-induced dominant mouse mutant, M-1156, that exhibits progressive retinal degeneration and to investigate the pathogenesis of the retinal phenotype in the mutant. METHODS: A positional candidate gene approach was used to identify the causative gene in...

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Detalles Bibliográficos
Autores principales: Sato, Hajime, Suzuki, Tomohiro, Ikeda, Kyoko, Masuya, Hiroshi, Sezutsu, Hideki, Kaneda, Hideki, Kobayashi, Kimio, Miura, Ikuo, Kurihara, Yasuyuki, Yokokura, Shunji, Nishida, Kohji, Tamai, Makoto, Gondo, Yoichi, Noda, Tetsuo, Wakana, Shigeharu
Formato: Texto
Lenguaje:English
Publicado: Molecular Vision 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838736/
https://www.ncbi.nlm.nih.gov/pubmed/20300562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838736/
https://www.ncbi.nlm.nih.gov/pubmed/20300562

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