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Decreasing the homodimer interaction: a common mechanism shared by the ΔG91 mutation and deamidation in βA3-crystallin
PURPOSE: Cataracts can be broadly divided into two types: congenital cataracts and age-related cataracts. ΔG91 is a previously discovered congenital mutation in βA3-crystallin that impairs protein solubility. On the other hand, the deamidation of β-crystallin is a significant feature in aged and cat...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Molecular Vision
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838740/ https://www.ncbi.nlm.nih.gov/pubmed/20300566 |