A Monomeric Variant of Insulin Degrading Enzyme (IDE) Loses Its Regulatory Properties

BACKGROUND: Insulin degrading enzyme (IDE) is a key enzyme in the metabolism of both insulin and amyloid beta peptides. IDE is unique in that it is subject to allosteric activation which is hypothesized to occur through an oligomeric structuture. METHODOLOGY/PRINCIPAL FINDINGS: IDE is known to exist...

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Detalles Bibliográficos
Autores principales: Song, Eun Suk, Rodgers, David W., Hersh, Louis B.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838795/
https://www.ncbi.nlm.nih.gov/pubmed/20300529
http://dx.doi.org/10.1371/journal.pone.0009719

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838795/
https://www.ncbi.nlm.nih.gov/pubmed/20300529
http://dx.doi.org/10.1371/journal.pone.0009719

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