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A Monomeric Variant of Insulin Degrading Enzyme (IDE) Loses Its Regulatory Properties
BACKGROUND: Insulin degrading enzyme (IDE) is a key enzyme in the metabolism of both insulin and amyloid beta peptides. IDE is unique in that it is subject to allosteric activation which is hypothesized to occur through an oligomeric structuture. METHODOLOGY/PRINCIPAL FINDINGS: IDE is known to exist...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
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Public Library of Science
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838795/ https://www.ncbi.nlm.nih.gov/pubmed/20300529 http://dx.doi.org/10.1371/journal.pone.0009719 |