Hypoxia Inactivates the VHL Tumor Suppressor through PIASy-Mediated SUMO Modification

The hypoxic microenvironment contributes to embryonic development and tumor progression through stabilization of the potent transcriptional factor HIFα. In normoxia, the tumor suppressor protein VHL acts as an E3 ubiquitin ligase to target HIFα for proteolytic destruction. Increasing evidence shows...

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Detalles Bibliográficos
Autores principales: Cai, Qiliang, Verma, Suhbash C., Kumar, Pankaj, Ma, Michelle, Robertson, Erle S.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838797/
https://www.ncbi.nlm.nih.gov/pubmed/20300531
http://dx.doi.org/10.1371/journal.pone.0009720

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838797/
https://www.ncbi.nlm.nih.gov/pubmed/20300531
http://dx.doi.org/10.1371/journal.pone.0009720

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