Cargando…

Hypoxia Inactivates the VHL Tumor Suppressor through PIASy-Mediated SUMO Modification

The hypoxic microenvironment contributes to embryonic development and tumor progression through stabilization of the potent transcriptional factor HIFα. In normoxia, the tumor suppressor protein VHL acts as an E3 ubiquitin ligase to target HIFα for proteolytic destruction. Increasing evidence shows...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cai, Qiliang, Verma, Suhbash C., Kumar, Pankaj, Ma, Michelle, Robertson, Erle S.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838797/ https://www.ncbi.nlm.nih.gov/pubmed/20300531 http://dx.doi.org/10.1371/journal.pone.0009720

Ejemplares similares

Ubiquitin/SUMO Modification Regulates VHL Protein Stability and Nucleocytoplasmic Localization
por: Cai, Qiliang, et al.
Publicado: (2010)

EC(5)S Ubiquitin Complex Is Recruited by KSHV Latent Antigen LANA for Degradation of the VHL and p53 Tumor Suppressors
por: Cai, Qi-Liang, et al.
Publicado: (2006)

A Unique SUMO-2-Interacting Motif within LANA Is Essential for KSHV Latency
por: Cai, Qiliang, et al.
Publicado: (2013)

Retraction: Ubiquitin/SUMO Modification Regulates VHL Protein Stability and Nucleocytoplasmic Localization
Publicado: (2022)

VHL inactivation without hypoxia is sufficient to achieve genome hypermethylation
por: Artemov, Artem V., et al.
Publicado: (2018)

SUMO E3 Ligase PIASy Mediates High Glucose-Induced Activation of NF-κB Inflammatory Signaling in Rat Mesangial Cells
por: Huang, Wei, et al.
Publicado: (2017)

RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2α
por: van Hagen, Martijn, et al.
Publicado: (2010)

Kaposi's Sarcoma Herpesvirus Upregulates Aurora A Expression to Promote p53 Phosphorylation and Ubiquitylation
por: Cai, Qiliang, et al.
Publicado: (2012)

Homeoprotein Msx1-PIASy Interaction Inhibits Angiogenesis
por: Son, Myung Jin, et al.
Publicado: (2020)

PIASy antagonizes Ras-driven NSCLC survival by promoting GATA2 SUMOylation
por: Chen, Bin, et al.
Publicado: (2018)

Deciphering von Hippel-Lindau (VHL/Vhl)-Associated Pancreatic Manifestations by Inactivating Vhl in Specific Pancreatic Cell Populations
por: Shen, H.-C. Jennifer, et al.
Publicado: (2009)

PIASy-dependent SUMOylation regulates DNA topoisomerase IIα activity
por: Ryu, Hyunju, et al.
Publicado: (2010)

SUMO Proteins are not Involved in TGF-β1-induced, Smad3/4-mediated Germline α Transcription, but PIASy Suppresses it in CH12F3-2A B Cells
por: Lee, Sang-Hoon, et al.
Publicado: (2014)

Sporadic hemangioblastomas are characterized by cryptic VHL inactivation
por: Shankar, Ganesh M, et al.
Publicado: (2014)

SUMO modification in apoptosis
por: Li, Peiyao, et al.
Publicado: (2020)

VHL and Hypoxia Signaling: Beyond HIF in Cancer
por: Zhang, Jing, et al.
Publicado: (2018)

Regulation of the tumor suppressor PTEN by SUMO
por: González-Santamaría, J, et al.
Publicado: (2012)

The VHL gene is epigenetically inactivated in pheochromocytomas and abdominal paragangliomas
por: Andreasson, Adam, et al.
Publicado: (2013)

An ID2-dependent mechanism for VHL inactivation in cancer
por: Lee, Sang Bae, et al.
Publicado: (2016)

STUB1 is targeted by the SUMO-interacting motif of EBNA1 to maintain Epstein-Barr Virus latency
por: Wang, Yuyan, et al.
Publicado: (2020)

Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene
por: Wykoff, C C, et al.
Publicado: (2004)

ZBRK1, a novel tumor suppressor, activates VHL gene transcription through formation of a complex with VHL and p300 in renal cancer
por: Chen, Ke, et al.
Publicado: (2015)

Inactivation of the tumor suppressor gene von Hippel-Lindau (VHL) in granulocytes contributes to development of liver hemangiomas in a mouse model
por: Bader, Hannah L., et al.
Publicado: (2016)

Hypoxia-inducible factor-2α stabilizes the von Hippel-Lindau (VHL) disease suppressor, Myb-related protein 2
por: Okumura, Fumihiko, et al.
Publicado: (2017)

Alcohol-induced autophagy via upregulation of PIASy promotes HCV replication in human hepatoma cells
por: Ran, Meihua, et al.
Publicado: (2018)

Comprehensive Analysis of LANA Interacting Proteins Essential for Viral Genome Tethering and Persistence
por: Verma, Subhash C., et al.
Publicado: (2013)

SUMO modification of PCNA is controlled by DNA
por: Parker, Joanne L, et al.
Publicado: (2008)

Perturbation of maternal PIASy abundance disrupts zygotic genome activation and embryonic development via SUMOylation pathway
por: Higuchi, Chika, et al.
Publicado: (2019)

Von Hippel-Lindau (VHL) Inactivation in Sporadic Clear Cell Renal Cancer: Associations with Germline VHL Polymorphisms and Etiologic Risk Factors
por: Moore, Lee E., et al.
Publicado: (2011)

VHL-1 inactivation and mitochondrial antioxidants rescue C. elegans dopaminergic neurodegeneration
por: Chen, Song, et al.
Publicado: (2019)

Loss of Von Hippel–Lindau (VHL) Tumor Suppressor Gene Function: VHL–HIF Pathway and Advances in Treatments for Metastatic Renal Cell Carcinoma (RCC)
por: Kim, Hyunho, et al.
Publicado: (2021)

DNA-dependent SUMO modification of PARP-1()
por: Zilio, Nicola, et al.
Publicado: (2013)

Insights in Post-Translational Modifications: Ubiquitin and SUMO
por: Salas-Lloret, Daniel, et al.
Publicado: (2022)

Oxygen-independent degradation of HIF-α via bioengineered VHL tumour suppressor complex
por: Sufan, Roxana I, et al.
Publicado: (2009)

Hsp90 chaperone code and the tumor suppressor VHL cooperatively regulate the mitotic checkpoint
por: Woodford, Mark R., et al.
Publicado: (2021)

VHL tumor suppressor as a novel potential candidate biomarker in papillary thyroid carcinoma
por: Todorović, Lidija, et al.
Publicado: (2023)

Expanding SUMO and ubiquitin-mediated signaling through hybrid SUMO-ubiquitin chains and their receptors
por: Guzzo, Catherine M., et al.
Publicado: (2013)

The RBP-Jκ Binding Sites within the RTA Promoter Regulate KSHV Latent Infection and Cell Proliferation
por: Lu, Jie, et al.
Publicado: (2012)

Acute Vhl Gene Inactivation Induces Cardiac HIF-Dependent Erythropoietin Gene Expression
por: Miró-Murillo, Marta, et al.
Publicado: (2011)

Mechanism of Adenovirus E4-ORF3-Mediated SUMO Modifications
por: Sohn, Sook-Young, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_g2d917g67632e87v89kad2pi1l