Pregnane × Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation

BACKGROUND: Clinical efficacy of chemotherapy in colorectal cancer is subjected to broad inter-individual variations leading to the inability to predict outcome and toxicity. The topoisomerase I inhibitor irinotecan (CPT-11) is worldwide approved for the treatment of metastatic colorectal cancer and...

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Detalles Bibliográficos
Autores principales: Raynal, Caroline, Pascussi, Jean-Marc, Leguelinel, Géraldine, Breuker, Cyril, Kantar, Jovana, Lallemant, Benjamin, Poujol, Sylvain, Bonnans, Caroline, Joubert, Dominique, Hollande, Frédéric, Lumbroso, Serge, Brouillet, Jean-Paul, Evrard, Alexandre
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838814/
https://www.ncbi.nlm.nih.gov/pubmed/20196838
http://dx.doi.org/10.1186/1476-4598-9-46

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838814/
https://www.ncbi.nlm.nih.gov/pubmed/20196838
http://dx.doi.org/10.1186/1476-4598-9-46

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