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Pregnane × Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation

BACKGROUND: Clinical efficacy of chemotherapy in colorectal cancer is subjected to broad inter-individual variations leading to the inability to predict outcome and toxicity. The topoisomerase I inhibitor irinotecan (CPT-11) is worldwide approved for the treatment of metastatic colorectal cancer and...

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Detalles Bibliográficos
Autores principales:	Raynal, Caroline, Pascussi, Jean-Marc, Leguelinel, Géraldine, Breuker, Cyril, Kantar, Jovana, Lallemant, Benjamin, Poujol, Sylvain, Bonnans, Caroline, Joubert, Dominique, Hollande, Frédéric, Lumbroso, Serge, Brouillet, Jean-Paul, Evrard, Alexandre
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838814/ https://www.ncbi.nlm.nih.gov/pubmed/20196838 http://dx.doi.org/10.1186/1476-4598-9-46

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