Ras activation of Erk restores impaired tonic BCR signaling and rescues immature B cell differentiation

B cell receptors (BCRs) generate tonic signals critical for B cell survival and early B cell development. To determine whether these signals also mediate the development of transitional and mature B cells, we examined B cell development using a mouse strain in which nonautoreactive immunoglobulin he...

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Detalles Bibliográficos
Autores principales: Rowland, Sarah L., DePersis, Corinne L., Torres, Raul M., Pelanda, Roberta
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839140/
https://www.ncbi.nlm.nih.gov/pubmed/20176802
http://dx.doi.org/10.1084/jem.20091673

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839140/
https://www.ncbi.nlm.nih.gov/pubmed/20176802
http://dx.doi.org/10.1084/jem.20091673

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