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Ras activation of Erk restores impaired tonic BCR signaling and rescues immature B cell differentiation
B cell receptors (BCRs) generate tonic signals critical for B cell survival and early B cell development. To determine whether these signals also mediate the development of transitional and mature B cells, we examined B cell development using a mouse strain in which nonautoreactive immunoglobulin he...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839140/ https://www.ncbi.nlm.nih.gov/pubmed/20176802 http://dx.doi.org/10.1084/jem.20091673 |