microRNA-29a induces aberrant self-renewal capacity in hematopoietic progenitors, biased myeloid development, and acute myeloid leukemia

The function of microRNAs (miRNAs) in hematopoietic stem cells (HSCs), committed progenitors, and leukemia stem cells (LSCs) is poorly understood. We show that miR-29a is highly expressed in HSC and down-regulated in hematopoietic progenitors. Ectopic expression of miR-29a in mouse HSC/progenitors r...

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Detalles Bibliográficos
Autores principales: Han, Yoon-Chi, Park, Christopher Y., Bhagat, Govind, Zhang, Jinping, Wang, Yulei, Fan, Jian-Bing, Liu, Mofang, Zou, Yongrui, Weissman, Irving L., Gu, Hua
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839143/
https://www.ncbi.nlm.nih.gov/pubmed/20212066
http://dx.doi.org/10.1084/jem.20090831

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839143/
https://www.ncbi.nlm.nih.gov/pubmed/20212066
http://dx.doi.org/10.1084/jem.20090831

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