Mycobacterium tuberculosis infection induces il12rb1 splicing to generate a novel IL-12Rβ1 isoform that enhances DC migration

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RNA splicing is an increasingly recognized regulator of immunity. Here, we demonstrate that after Mycobacterium tuberculosis infection (mRNA) il12rb1 is spliced by dendritic cells (DCs) to form an alternative (mRNA) il12rb1Δtm that encodes the protein IL-12Rβ1ΔTM. Compared with IL-12Rβ1, IL-12Rβ1ΔTM...

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Detalles Bibliográficos
Autores principales: Robinson, Richard T., Khader, Shabaana A., Martino, Cynthia A., Fountain, Jeffrey J., Teixeira-Coelho, Maria, Pearl, John E., Smiley, Stephen T., Winslow, Gary M., Woodland, David L., Walter, Michael J., Conejo-Garcia, Jose R., Gubler, Ueli, Cooper, Andrea M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839154/
https://www.ncbi.nlm.nih.gov/pubmed/20212068
http://dx.doi.org/10.1084/jem.20091085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839154/
https://www.ncbi.nlm.nih.gov/pubmed/20212068
http://dx.doi.org/10.1084/jem.20091085

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