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Mycobacterium tuberculosis infection induces il12rb1 splicing to generate a novel IL-12Rβ1 isoform that enhances DC migration
RNA splicing is an increasingly recognized regulator of immunity. Here, we demonstrate that after Mycobacterium tuberculosis infection (mRNA) il12rb1 is spliced by dendritic cells (DCs) to form an alternative (mRNA) il12rb1Δtm that encodes the protein IL-12Rβ1ΔTM. Compared with IL-12Rβ1, IL-12Rβ1ΔTM...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839154/ https://www.ncbi.nlm.nih.gov/pubmed/20212068 http://dx.doi.org/10.1084/jem.20091085 |
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por Robinson, Richard T., Khader, Shabaana A., Martino, Cynthia A., Fountain, Jeffrey J., Teixeira-Coelho, Maria, Pearl, John E., Smiley, Stephen T., Winslow, Gary M., Woodland, David L., Walter, Michael J., Conejo-Garcia, Jose R., Gubler, Ueli, Cooper, Andrea M.
Publicado 2010
Enlace del recurso
Publicado 2010
Enlace del recurso
Texto