Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis

DNAX adaptor protein 12 (DAP12) is a trans-membrane adaptor molecule that transduces activating signals in NK and myeloid cells. Absence of functional Dap12 results in osteoclast defects and bone abnormalities. Because DAP12 has no extracelluar binding domains, it must pair with cell surface recepto...

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Detalles Bibliográficos
Autores principales: Joyce-Shaikh, Barbara, Bigler, Michael E., Chao, Cheng-Chi, Murphy, Erin E., Blumenschein, Wendy M., Adamopoulos, Iannis E., Heyworth, Paul G., Antonenko, Svetlana, Bowman, Edward P., McClanahan, Terrill K., Phillips, Joseph H., Cua, Daniel J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839155/
https://www.ncbi.nlm.nih.gov/pubmed/20212065
http://dx.doi.org/10.1084/jem.20090516

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839155/
https://www.ncbi.nlm.nih.gov/pubmed/20212065
http://dx.doi.org/10.1084/jem.20090516

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