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Preparation and Evaluation of Soft Gellan Gum Gel Containing Paracetamol

The objective of this study was to develop soft paracetamol gel using gellan gum as a gelling agent and sodium citrate as a source of cation. Different batches were prepared using three different concentrations of gellan gum (0.1, 0.3, and 0.5%), each with two different sodium citrate concentrations...

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Detalles Bibliográficos
Autores principales: Gohel, M. C., Parikh, R. K., Nagori, S. A., Shah, S. N., Dabhi, M. R.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839393/
https://www.ncbi.nlm.nih.gov/pubmed/20336205
http://dx.doi.org/10.4103/0250-474X.54273
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author Gohel, M. C.
Parikh, R. K.
Nagori, S. A.
Shah, S. N.
Dabhi, M. R.
author_facet Gohel, M. C.
Parikh, R. K.
Nagori, S. A.
Shah, S. N.
Dabhi, M. R.
author_sort Gohel, M. C.
collection PubMed
description The objective of this study was to develop soft paracetamol gel using gellan gum as a gelling agent and sodium citrate as a source of cation. Different batches were prepared using three different concentrations of gellan gum (0.1, 0.3, and 0.5%), each with two different sodium citrate concentrations (0.3 and 0.5%). The consistency of the paracetamol gel was dependent on the concentration of gellan gum, sodium citrate and co-solute. The results of dissolution study of soft gel containing 0.3% gellan gum and 0.3% sodium citrate revealed that paracetamol was completely released in 30 min. Polyethylene glycol 400 worked as a solubilizer for paracetamol. All the gels possessed acceptable sensory characteristics when evaluated by human volunteers. Short term stability study carried out for four weeks at different temperatures revealed no considerable changes in performance characteristics of developed optimized formulation.
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spelling pubmed-28393932010-03-24 Preparation and Evaluation of Soft Gellan Gum Gel Containing Paracetamol Gohel, M. C. Parikh, R. K. Nagori, S. A. Shah, S. N. Dabhi, M. R. Indian J Pharm Sci Short Communications The objective of this study was to develop soft paracetamol gel using gellan gum as a gelling agent and sodium citrate as a source of cation. Different batches were prepared using three different concentrations of gellan gum (0.1, 0.3, and 0.5%), each with two different sodium citrate concentrations (0.3 and 0.5%). The consistency of the paracetamol gel was dependent on the concentration of gellan gum, sodium citrate and co-solute. The results of dissolution study of soft gel containing 0.3% gellan gum and 0.3% sodium citrate revealed that paracetamol was completely released in 30 min. Polyethylene glycol 400 worked as a solubilizer for paracetamol. All the gels possessed acceptable sensory characteristics when evaluated by human volunteers. Short term stability study carried out for four weeks at different temperatures revealed no considerable changes in performance characteristics of developed optimized formulation. Medknow Publications 2009 /pmc/articles/PMC2839393/ /pubmed/20336205 http://dx.doi.org/10.4103/0250-474X.54273 Text en © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communications
Gohel, M. C.
Parikh, R. K.
Nagori, S. A.
Shah, S. N.
Dabhi, M. R.
Preparation and Evaluation of Soft Gellan Gum Gel Containing Paracetamol
title Preparation and Evaluation of Soft Gellan Gum Gel Containing Paracetamol
title_full Preparation and Evaluation of Soft Gellan Gum Gel Containing Paracetamol
title_fullStr Preparation and Evaluation of Soft Gellan Gum Gel Containing Paracetamol
title_full_unstemmed Preparation and Evaluation of Soft Gellan Gum Gel Containing Paracetamol
title_short Preparation and Evaluation of Soft Gellan Gum Gel Containing Paracetamol
title_sort preparation and evaluation of soft gellan gum gel containing paracetamol
topic Short Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839393/
https://www.ncbi.nlm.nih.gov/pubmed/20336205
http://dx.doi.org/10.4103/0250-474X.54273
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