Enantioselective synthesis of tricyclic amino acid derivatives based on a rigid 4-azatricyclo[5.2.1.0(2,6)]decane skeleton

An enantioselective route to four tricyclic amino acids and N-tosylamides, composed of a central norbornane framework with a 2-endo,3-endo-annelated pyrrolidine ring and a 5-endo-C(1) or -C(2) side chain, has been developed. A key intermediate was the chiral, N-Boc-protected ketone (1R,2S,6S,7R)-4-a...

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Detalles Bibliográficos
Autores principales: Breuning, Matthias, Häuser, Tobias, Mehler, Christian, Däschlein, Christian, Strohmann, Carsten, Oechsner, Andreas, Braunschweig, Holger
Formato: Texto
Lenguaje:English
Publicado: Beilstein-Institut 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839531/
https://www.ncbi.nlm.nih.gov/pubmed/20300505
http://dx.doi.org/10.3762/bjoc.5.81