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Economic and Practical Factors in Diagnosing HNPCC Using Clinical Criteria, Immunohistochemistry and Microsatellite Instability Analysis
AIM: To determine a cost-efficient strategy for HNPCC molecular diagnostic testing. METHODS: 138 families referred to a Regional Genetics Service had hMLH1 and hMSH2 mutation analysis. The sensitivity and specificity of clinical selection criteria with or without immunohistochemistry (IHC) and micro...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2004
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840004/ https://www.ncbi.nlm.nih.gov/pubmed/20233461 http://dx.doi.org/10.1186/1897-4287-2-4-175 |