Contribution of the Defective BRCA1, BRCA2 and CHEK2 Genes to the Familial Aggregation of Breast Cancer: a Simulation Study Based on the Swedish Family-Cancer Database

The known breast cancer susceptibility genes only account for 20% to 25% of the excess familial risk of the disease [1]. The present study assessed the contribution of BRCA1/2 mutations and CHEK2 variants to the relative risk of breast cancer for women with affected mothers or sisters. The familial...

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Detalles Bibliográficos
Autores principales: Bermejo, Justo Lorenzo, Pérez, Alfonso García, Hemminki, Kari
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840005/
https://www.ncbi.nlm.nih.gov/pubmed/20233462
http://dx.doi.org/10.1186/1897-4287-2-4-185

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840005/
https://www.ncbi.nlm.nih.gov/pubmed/20233462
http://dx.doi.org/10.1186/1897-4287-2-4-185

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