Sodium valproate-induced congenital cardiac abnormalities in mice are associated with the inhibition of histone deacetylase

BACKGROUND: Valproic acid, a widely used anticonvulsant drug, is a potent teratogen resulting in various congenital abnormalities. However, the mechanisms underlying valproic acid induced teratogenesis are nor clear. Recent studies indicate that histone deacetylase is a direct target of valproic aci...

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Detalles Bibliográficos
Autores principales: Wu, Gang, Nan, Changlong, Rollo, Johnathon C, Huang, Xupei, Tian, Jie
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841099/
https://www.ncbi.nlm.nih.gov/pubmed/20219112
http://dx.doi.org/10.1186/1423-0127-17-16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841099/
https://www.ncbi.nlm.nih.gov/pubmed/20219112
http://dx.doi.org/10.1186/1423-0127-17-16

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