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Sodium valproate-induced congenital cardiac abnormalities in mice are associated with the inhibition of histone deacetylase
BACKGROUND: Valproic acid, a widely used anticonvulsant drug, is a potent teratogen resulting in various congenital abnormalities. However, the mechanisms underlying valproic acid induced teratogenesis are nor clear. Recent studies indicate that histone deacetylase is a direct target of valproic aci...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841099/ https://www.ncbi.nlm.nih.gov/pubmed/20219112 http://dx.doi.org/10.1186/1423-0127-17-16 |