Cargando…

Reduction of β-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease

BACKGROUND: Aβ deposits represent a neuropathological hallmark of Alzheimer's disease (AD). Both soluble and insoluble Aβ species are considered to be responsible for initiating the pathological cascade that eventually leads to AD. Therefore, the identification of therapeutic approaches that ca...

Descripción completa

Detalles Bibliográficos
Autores principales:	Paris, Daniel, Ganey, Nowell J, Laporte, Vincent, Patel, Nikunj S, Beaulieu-Abdelahad, David, Bachmeier, Corbin, March, Amelia, Ait-Ghezala, Ghania, Mullan, Michael J
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841120/ https://www.ncbi.nlm.nih.gov/pubmed/20211007 http://dx.doi.org/10.1186/1742-2094-7-17

Ejemplares similares

Flavonoids lower Alzheimer's Aβ production via an NFκB dependent mechanism
por: Paris, Daniel, et al.
Publicado: (2011)

Amelioration of Experimental Autoimmune Encephalomyelitis by Anatabine
por: Paris, Daniel, et al.
Publicado: (2013)

Chronic Anatabine Treatment Reduces Alzheimer’s Disease (AD)-Like Pathology and Improves Socio-Behavioral Deficits in a Transgenic Mouse Model of AD
por: Verma, Megha, et al.
Publicado: (2015)

Correction: Chronic Anatabine Treatment Reduces Alzheimer's Disease (AD)-Like Pathology and Improves Socio-Behavioral Deficits in a Transgenic Mouse Model of AD
por: Verma, Megha, et al.
Publicado: (2015)

CD40 deficiency mitigates Alzheimer's disease pathology in transgenic mouse models
por: Laporte, Vincent, et al.
Publicado: (2006)

Alzheimer’s disease pathological lesions activate the spleen tyrosine kinase
por: Schweig, Jonas Elias, et al.
Publicado: (2017)

MMP9 modulation improves specific neurobehavioral deficits in a mouse model of Alzheimer’s disease
por: Ringland, Charis, et al.
Publicado: (2021)

A 3D-QSAR model based screen for dihydropyridine-like compound library to identify inhibitors of amyloid beta (Aβ) production
por: Mathura, Venkatarajan S, et al.
Publicado: (2010)

Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer's disease
por: Patel, Nikunj S, et al.
Publicado: (2005)

Lifelong behavioral and neuropathological consequences of repetitive mild traumatic brain injury
por: Mouzon, Benoit C., et al.
Publicado: (2017)

Feasibility of Predicting MCI/AD Using Neuropsychological Tests and Serum β-Amyloid
por: Luis, Cheryl A., et al.
Publicado: (2011)

A fast, miniaturised in-vitro assay developed for quantification of lipase enzyme activity
por: Menden, Ariane, et al.
Publicado: (2019)

Bacopa monnieri supplementation has no effect on serum brain-derived neurotrophic factor levels but beneficially modulates nuclear factor kappa B and cyclic AMP response element-binding protein levels in healthy elderly subjects
por: Keegan, Andrew P., et al.
Publicado: (2023)

Molecular Pathobiology of the Cerebrovasculature in Aging and in Alzheimers Disease Cases With Cerebral Amyloid Angiopathy
por: Ojo, Joseph O., et al.
Publicado: (2021)

The Influence of Baseline Alzheimer's Disease Severity on Cognitive Decline and CSF Biomarkers in the NILVAD Trial
por: Abdullah, Laila, et al.
Publicado: (2020)

Adaptive Immune Responses Associated with the Central Nervous System Pathology of Gulf War Illness
por: Nkiliza, Aurore, et al.
Publicado: (2021)

Exogenous lipase administration alters gut microbiota composition and ameliorates Alzheimer’s disease-like pathology in APP/PS1 mice
por: Menden, Ariane, et al.
Publicado: (2022)

Complementary proteomic approaches reveal mitochondrial dysfunction, immune and inflammatory dysregulation in a mouse model of Gulf War Illness
por: Zakirova, Zuchra, et al.
Publicado: (2017)

Gulf War Agent Exposure Causes Impairment of Long-Term Memory Formation and Neuropathological Changes in a Mouse Model of Gulf War Illness
por: Zakirova, Zuchra, et al.
Publicado: (2015)

Proteomic Identification of Pathways Responsible for the Estradiol Therapeutic Window in AD Animal Models
por: Cui, Jie, et al.
Publicado: (2019)

Celastrol Attenuates Learning and Memory Deficits in an Alzheimer's Disease Rat Model
por: Xiao, Yao, et al.
Publicado: (2021)

Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids
por: Wang, Huabo, et al.
Publicado: (2015)

Systematic identification of Celastrol-binding proteins reveals that Shoc2 is inhibited by Celastrol
por: Xiao-pei, Huang, et al.
Publicado: (2018)

A Chronic Longitudinal Characterization of Neurobehavioral and Neuropathological Cognitive Impairment in a Mouse Model of Gulf War Agent Exposure
por: Zakirova, Zuchra, et al.
Publicado: (2016)

Venular amyloid accumulation in transgenic Fischer 344 Alzheimer’s disease rats
por: Bishay, J., et al.
Publicado: (2022)

Correction: Systematic identification of celastrol-binding proteins reveals that Shoc2 is inhibited by celastrol
Publicado: (2021)

Antibody-Based In Vivo PET Imaging Detects Amyloid-β Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition
por: Meier, Silvio R., et al.
Publicado: (2018)

APOE genotype dependent molecular abnormalities in the cerebrovasculature of Alzheimer’s disease and age-matched non-demented brains
por: Ojo, Joseph O., et al.
Publicado: (2021)

Impact of gulf war toxic exposures after mild traumatic brain injury
por: Ferguson, Scott, et al.
Publicado: (2022)

Phenotypic analysis of a transgenic Drosophila model of Alzheimer’s amyloid-β toxicity
por: Sekiya, Michiko, et al.
Publicado: (2021)

Animal Models of Alzheimer’s Disease: Utilization of Transgenic Alzheimer’s Disease Models in Studies of Amyloid Beta Clearance
por: Malm, Tarja, et al.
Publicado: (2012)

Influence of traumatic brain injury on extracellular tau elimination at the blood–brain barrier
por: Eisenbaum, Maxwell, et al.
Publicado: (2021)

Baicalein reduces β-amyloid and promotes nonamyloidogenic amyloid precursor protein processing in an Alzheimer’s disease transgenic mouse model
por: Zhang, She-Qing, et al.
Publicado: (2013)

Formulation and Evaluation of Celastrol-Loaded Liposomes
por: Song, Jie, et al.
Publicado: (2011)

Autophagy in the pharmacological activities of celastrol (Review)
por: Zhang, Caixia, et al.
Publicado: (2023)

Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota
por: Harach, T., et al.
Publicado: (2017)

Phospholipid profiling of plasma from GW veterans and rodent models to identify potential biomarkers of Gulf War Illness
por: Emmerich, Tanja, et al.
Publicado: (2017)

APOE ε4 specific imbalance of arachidonic acid and docosahexaenoic acid in serum phospholipids identifies individuals with preclinical Mild Cognitive Impairment/Alzheimer's Disease
por: Abdullah, Laila, et al.
Publicado: (2017)

Lipocalin 2 Does Not Play A Role in Celastrol-Mediated Reduction in Food Intake and Body Weight
por: Feng, Xudong, et al.
Publicado: (2019)

Mural cell dysfunction leads to altered cerebrovascular tau uptake following repetitive head trauma
por: Ojo, Joseph, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_76lqhc14g7ae3rurpaqf97pq7l