Regulation of P-Glycoprotein in Renal Proximal Tubule Epithelial Cells by LPS and TNF-α

During endotoxemia, the ATP-dependent drug efflux pump P-glycoprotein (Abcb1/P-gp) is upregulated in kidney proximal tubule epithelial cells. The signaling pathway through which lipopolysaccharide (LPS) or tumor necrosis factor-α (TNF-α) regulates P-gp expression and activity was investigated furthe...

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Detalles Bibliográficos
Autores principales: Heemskerk, Suzanne, Peters, Janny G. P., Louisse, Jochem, Sagar, Seil, Russel, Frans G. M., Masereeuw, Rosalinde
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841251/
https://www.ncbi.nlm.nih.gov/pubmed/20300455
http://dx.doi.org/10.1155/2010/525180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841251/
https://www.ncbi.nlm.nih.gov/pubmed/20300455
http://dx.doi.org/10.1155/2010/525180

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