Small Molecule Inhibitors of the Neuropilin-1 Vascular Endothelial Growth Factor A (VEGF-A) Interaction

[Image: see text] We report the molecular design and synthesis of EG00229, 2, the first small molecule ligand for the VEGF-A receptor neuropilin 1 (NRP1) and the structural characterization of NRP1−ligand complexes by NMR spectroscopy and X-ray crystallography. Mutagenesis studies localized VEGF-A b...

Descripción completa

Detalles Bibliográficos
Autores principales: Jarvis, Ashley, Allerston, Charles K., Jia, Haiyan, Herzog, Birger, Garza-Garcia, Acely, Winfield, Natalie, Ellard, Katie, Aqil, Rehan, Lynch, Rosemary, Chapman, Chris, Hartzoulakis, Basil, Nally, James, Stewart, Mark, Cheng, Lili, Menon, Malini, Tickner, Michelle, Djordjevic, Snezana, Driscoll, Paul C., Zachary, Ian, Selwood, David L.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2010
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841442/
https://www.ncbi.nlm.nih.gov/pubmed/20151671
http://dx.doi.org/10.1021/jm901755g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841442/
https://www.ncbi.nlm.nih.gov/pubmed/20151671
http://dx.doi.org/10.1021/jm901755g

Ejemplares similares