Regression of murine lung tumors by the let-7 microRNA

MicroRNAs (miRNAs) have recently emerged as an important new class of cellular regulators that control various cellular processes and are implicated in human diseases, including cancer. Here, we show that loss of let-7 function enhances lung tumor formation in vivo, strongly supporting the hypothesi...

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Autores principales: Trang, Phong, Medina, Pedro P., Wiggins, Jason F., Ruffino, Lynnsie, Kelnar, Kevin, Omotola, Michael, Homer, Robert, Brown, David, Bader, Andreas G., Weidhaas, Joanne B., Slack, Frank J.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841713/
https://www.ncbi.nlm.nih.gov/pubmed/19966857
http://dx.doi.org/10.1038/onc.2009.445
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author Trang, Phong
Medina, Pedro P.
Wiggins, Jason F.
Ruffino, Lynnsie
Kelnar, Kevin
Omotola, Michael
Homer, Robert
Brown, David
Bader, Andreas G.
Weidhaas, Joanne B.
Slack, Frank J.
author_facet Trang, Phong
Medina, Pedro P.
Wiggins, Jason F.
Ruffino, Lynnsie
Kelnar, Kevin
Omotola, Michael
Homer, Robert
Brown, David
Bader, Andreas G.
Weidhaas, Joanne B.
Slack, Frank J.
author_sort Trang, Phong
collection PubMed
description MicroRNAs (miRNAs) have recently emerged as an important new class of cellular regulators that control various cellular processes and are implicated in human diseases, including cancer. Here, we show that loss of let-7 function enhances lung tumor formation in vivo, strongly supporting the hypothesis that let-7 is a tumor suppressor. Moreover, we report that exogenous delivery of let-7 to established tumors in mouse models of non-small cell lung cancer (NSCLC) significantly reduces tumor burden. These results demonstrate the therapeutic potential of let-7 in NSCLC and point to miRNA replacement therapy as a promising approach in cancer treatment.
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spelling pubmed-28417132010-09-18 Regression of murine lung tumors by the let-7 microRNA Trang, Phong Medina, Pedro P. Wiggins, Jason F. Ruffino, Lynnsie Kelnar, Kevin Omotola, Michael Homer, Robert Brown, David Bader, Andreas G. Weidhaas, Joanne B. Slack, Frank J. Oncogene Article MicroRNAs (miRNAs) have recently emerged as an important new class of cellular regulators that control various cellular processes and are implicated in human diseases, including cancer. Here, we show that loss of let-7 function enhances lung tumor formation in vivo, strongly supporting the hypothesis that let-7 is a tumor suppressor. Moreover, we report that exogenous delivery of let-7 to established tumors in mouse models of non-small cell lung cancer (NSCLC) significantly reduces tumor burden. These results demonstrate the therapeutic potential of let-7 in NSCLC and point to miRNA replacement therapy as a promising approach in cancer treatment. 2009-12-07 2010-03-18 /pmc/articles/PMC2841713/ /pubmed/19966857 http://dx.doi.org/10.1038/onc.2009.445 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Trang, Phong
Medina, Pedro P.
Wiggins, Jason F.
Ruffino, Lynnsie
Kelnar, Kevin
Omotola, Michael
Homer, Robert
Brown, David
Bader, Andreas G.
Weidhaas, Joanne B.
Slack, Frank J.
Regression of murine lung tumors by the let-7 microRNA
title Regression of murine lung tumors by the let-7 microRNA
title_full Regression of murine lung tumors by the let-7 microRNA
title_fullStr Regression of murine lung tumors by the let-7 microRNA
title_full_unstemmed Regression of murine lung tumors by the let-7 microRNA
title_short Regression of murine lung tumors by the let-7 microRNA
title_sort regression of murine lung tumors by the let-7 microrna
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841713/
https://www.ncbi.nlm.nih.gov/pubmed/19966857
http://dx.doi.org/10.1038/onc.2009.445
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